Home Chemistry Heterocyclic Building Blocks Benzimidazoles 1-Phenyl-1H-Benzo[D]Imidazole
Acylation: You can acylate the nitrogen atom in the imidazole ring using acyl chlorides or anhydrides to form amides. For example, reacting with acetyl chloride would give N-acetyl-1-phenyl-1H-benzo[d]imidazole.
Alkylation: The nitrogen atom in the imidazole ring can be alkylated using alkyl halides or alkylating agents to introduce alkyl groups at the N position.
Halogenation: The phenyl ring can undergo electrophilic aromatic substitution reactions, such as halogenation (e.g., bromination or chlorination), to introduce halogen atoms onto the ring.
Reduction: Reduction reactions can be used to convert the imidazole ring into a dihydroimidazole or tetrahydroimidazole, depending on the reagents and conditions used.
Oxidation: Oxidation reactions can be employed to convert the compound to its corresponding N-oxide or other oxidized derivatives.
Cyclization: Intramolecular reactions can lead to the formation of fused ring systems or other cyclized products depending on the reaction conditions and the functional groups present.
Substitution reactions: The phenyl group can undergo various substitution reactions, such as nitration, sulfonation, or Friedel-Crafts reactions, to introduce different substituents onto the aromatic ring.
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2-Methyl-1-phenyl-1H-benzo[d]imidazole-5-carboxylic acid
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1-(2-Methoxyphenyl)-1H-benzo[d]imidazol-5-amine
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(1-Phenyl-1H-benzo[d]imidazol-5-yl)boronic acid
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